Activation of the Transcription Factor NFAT5 in the Tumor Microenvironment Enforces CD8+ T Cell Exhaustion

Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8M+ T cell exhaustion.