Cigarette Smoke Restricts the Ability of Mesenchymal Cells to Support Lung Epithelial Organoid Formation

The authors assessed the effect of cigarette smoke-exposure and the endoplasmic reticulum stress inducer Thapsigargin on Wnt/β-catenin signaling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation.