The USP7-STAT3-Granzyme-Par-1 Axis Regulates Allergic Inflammation by Promoting Differentiation of IL-5-Producing Th2 Cells

The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]