Notoginsenoside R1 Promotes Lgr5⁺ Stem Cell and Epithelium Renovation in Colitis Mice via Activating Wnt/β-Catenin Signaling

The authors investigated the reparative effects of notoginsenoside R1 (NGR1) on mucosal barrier damage after the acute injury stage of DSS exposure. NGR1 (100 μM) also increased Lgr5+ cells and budding rates in a 3D intestinal organoid model. They demonstrated that NGR1 promoted intestinal stem cell proliferation and differentiation through activation of the Wnt signaling pathway.