Choroid Plexus Defects in Down Syndrome Brain Organoids Enhance Neurotropism of SARS-CoV-2

Scientists demonstrated that the choroid plexus (ChP)-like epithelium facilitated infection and replication of SARS-CoV-2 in cortical neurons and that this is increased in Down syndrome (DS) established brain organoids from DS and isogenic euploid iPSC that consist of a core of functional cortical neurons surrounded by a functional ChP-like epithelium.
[Science Advances]
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