Melatonin Mitigates Chemotherapy-Induced Small Intestinal Atrophy in Rats and Reduces Cytotoxicity in Murine Intestinal Organoids

The authors elucidated the potential of melatonin and misoprostol to reduce 5-fluorouracil-induced small intestinal mucositis. Morphological and cellular changes in the jejunum, along with colonic faecal water content were quantified in rats as markers for chemotherapy-induced mucositis.