Epstein-Barr Virus Infection Promotes T Cell Dysregulation in a Humanized Mouse Model of Multiple Sclerosis

Donor Epstein-Barr virus (EBV) seropositivity and relapsing multiple sclerosis diagnosis were associated with a significant increase in the number of central nervous system (CNS) infiltrating effector T cells due to enhanced proliferation of proinflammatory T cells and limited expansion of regulatory T cells.