Newsletters

[Nature Biomedical Engineering] Scientists developed a neutrophil-specific modified RNA translation platform, termed NeuSMRT, that enables the expression of CARs in primary neutrophils. In a syngeneic glioma model, CAR-neutrophils produced in vivo significantly inhibited tumour growth and prolong survival.

[Nature Reviews Bioengineering] The authors discuss different CAR-engineered immune cells for therapeutic applications by highlighting how unique immune attributes, along with cell-specific manufacturing strategies and CAR designs, address challenges faced by conventional CAR-T cell therapy.

[Signal Transduction and Targeted Therapy] Scientists revealed that venetoclax treatment during ex vivo expansion of CART cells, prepared from T cells from healthy donors or chemotherapeutically pretreated patients, potently augments antitumor efficacy in a BCL-2-dependent manner.

[Cancer Gene Therapy] Scientists developed a vaccine approach against colorectal cancers expressing a mutant p53 protein. The immunized animals had significantly decreased tumor size, prolonged survival and increased tumor CD8+ T cell infiltrates.

[Cell Death & Disease] Scientists investigated the spatiotemporal dynamics of macrophage populations in molars and surrounding tissues during postnatal root development in mice. Gli1⁺ MSCs exhibited increased proliferation but impaired osteo/odontogenic differentiation upon macrophage depletion.

[Scientific Reports] Investigators treated bleomycin-induced pulmonary fibrosis in rats with MSCs, metformin, or their combination. Combination therapy most effectively corrected metabolic disruptions and attenuated fibrotic remodeling.

[Cell Death & Disease] Using a Smad4 loss-of-function and β-catenin gain-of-function mouse model, researchers demonstrated that dedifferentiation-derived oncogenic stem cells sustain tumorigenesis more effectively than endogenous mutant stem cells harboring the mutation.

[Molecular Therapy Oncology] Using patient-derived, drug-resistant metastatic ovarian cancer models, investigators showed that exposure to SN38 or 5-FU upregulates NKG2D stress ligands on CSCs, enhancing their susceptibility to NK-mediated cytotoxicity.

[Acta Pharmacologica Sinica] Researchers revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in triple-negative breast cancer.

[Nature Cell Biology] Scientists characterized longitudinal bone marrow niches supporting LSC survival, distinguishing the metaphysis from the central marrow.

[Nature Reviews Cancer] The authors summarize microenvironmental drivers of dormancy, including the role of niche-derived signals and extracellular matrix composition in maintaining disseminated cancer cell quiescence, as well as the epigenetic and transcriptional programmes, and chromatin remodelling that enforce and sustain dormancy.

[Nature Communications] Investigators showed that the whole-transcriptome profile of CSCs from skin squamous cell carcinoma patients reveals upregulation in expression of genes associated with global hypermethylation, enhanced non-canonical Wnt signaling, and glycolysis, thereby activating the c-Jun/Sox2/Hif1α axis.