Transmembrane TNF-TNFR2 Signaling as a Critical Immunoregulatory Node in Pancreatic Cancer

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Researchers described that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T cell dysfunction – two hallmarks of therapeutic resistance.
[Oncoimmunology]
Abstract