Intestinal Tuft Cell Immune Privilege Enables Norovirus Persistence

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To examine how tuft cells promote immune escape, investigators interrogated tuft cell interactions with CD8+ T cells by adoptively transferring just EGFP death inducing CD8+ T cells into Gfi1b-GFP tuft cell reporter mice. Investigators showed that intestinal tuft cells were relatively resistant to CD8+ T cells independent of norovirus infection, representing an immune-privileged niche that can be leveraged by enteric microbes.
[Science Immunology]
Abstract