Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsHuman umbilical cord blood-MSCs were infected with the adenovirus expressing GFP-VEFG fusion protein to overexpress VEGF165 or the adenovirus expressing GFP as control.
[Journal of Gene Medicine]
6445218 RDJ7G4QT items 1 apa 0 default asc 1 163082 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-e94db08690fb13fdcdbaeadfe14a5357%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RDJ7G4QT%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chen%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChen%2C%20H.%2C%20Tang%2C%20S.%2C%20Liao%2C%20J.%2C%20Liu%2C%20M.%2C%20%26amp%3B%20Lin%2C%20Y.%20%28n.d.%29.%20VEGF165%20gene-modified%20human%20umbilical%20cord%20blood%20mesenchymal%20stem%20cells%20protect%20against%20acute%20liver%20failure%20in%20rats.%20%3Ci%3EThe%20Journal%20of%20Gene%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29%2C%20e3369.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjgm.3369%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjgm.3369%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DRDJ7G4QT%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22VEGF165%20gene-modified%20human%20umbilical%20cord%20blood%20mesenchymal%20stem%20cells%20protect%20against%20acute%20liver%20failure%20in%20rats%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haiou%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shigang%22%2C%22lastName%22%3A%22Tang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinmao%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meng%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yihe%22%2C%22lastName%22%3A%22Lin%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Human%20umbilical%20cord%20blood%20mesenchymal%20stem%20cells%20%28HUCB-MSCs%29%20can%20exert%20protective%20effect%20on%20rat%20models%20of%20acute%20liver%20failure%20%28ALF%29.%20Vascular%20endothelial%20growth%20factor%20165%20%28VEGF165%29%20is%20the%20predominant%20VEGF%20isoform%20and%20possesses%20a%20strong%20pro-angiogenic%20function.%20In%20this%20study%2C%20HUCB-MSC%20was%20served%20as%20the%20gene-delivery%20vehicle%20for%20VEGF165%20gene%2C%20and%20we%20explored%20the%20therapeutic%20effects%20of%20this%20system%20on%20ALF.%20Methods%20HUCB-MSCs%20were%20infected%20with%20the%20adenovirus%20expressing%20GFP-VEFG%20fusion%20protein%20%28Ad-VEGF165%29%20to%20overexpress%20VEGF165%20or%20the%20adenovirus%20expressing%20GFP%20%28Ad-GFP%29%20as%20control.%20The%20control%20and%20modified%20HUCB-MSCs%20were%20then%20transplanted%20into%20ALF%20model%20rats.%20Liver%20function%20and%20liver%20pathological%20changes%20were%20assessed%20by%20biochemical%20tests%20and%20liver%20histology.%20Immunohistochemistry%20was%20carried%20out%20to%20determine%20the%20expression%20of%20BrdU%2C%20CD34%2C%20Ki67%2C%20and%20VEGF.%20Results%20VEGF165%20overexpression%20enhanced%20the%20multipotency%20of%20HUCB-MSCs%20and%20promoted%20the%20homing%20and%20colonization%20of%20HUCB-MSC%20in%20the%20liver%20tissues%20of%20ALF%20rats.%20Furthermore%2C%20although%20HUCB-MSCs%20transplantation%20ameliorated%20liver%20damage%20and%20promoted%20liver%20regeneration%20to%20some%20extent%20in%20ALF%20rats%2C%20Ad-VEGF165-HUCB-MSCs%20transplantation%20showed%20stronger%20therapeutic%20effects%20on%20ALF.%20Conclusions%20In%20summary%2C%20transplantation%20of%20VEGF165-modified%20HUCB-MSCs%20exerts%20stronger%20therapeutic%20effects%20on%20ALF%20than%20HUCB-MSCs.%20This%20study%20provides%20a%20novel%20therapeutic%20approach%20for%20ALF.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjgm.3369%22%2C%22ISSN%22%3A%221521-2254%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fjgm.3369%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-03T23%3A05%3A49Z%22%7D%7D%5D%7D
Chen, H., Tang, S., Liao, J., Liu, M., & Lin, Y. (n.d.). VEGF165 gene-modified human umbilical cord blood mesenchymal stem cells protect against acute liver failure in rats. The Journal of Gene Medicine, n/a(n/a), e3369. https://doi.org/https://doi.org/10.1002/jgm.3369 Cite
