Umbilical Cord-Derived Mesenchymal Stem Cells Promote Myeloid-Derived Suppressor Cell Enrichment by Secreting CXCL1 to Prevent Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation

Human umbilical cord-derived MSCs effectively decreased the incidence and severity of graft-versus-host disease (GVHD), which was mediated by the enrichment of myeloid-derived suppressor cells in GVHD target tissues.