ADGRG1 Enriches for Functional Human Hematopoietic Stem Cells Following Ex Vivo Expansion-Induced Mitochondrial Oxidative Stress

By
Justin.choi
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Investigators reported that the frequencies of SCID repopulating cells were greatly decreased in cord blood CD34+ hematopoietic stem cells and hematopoietic progenitor cells upon ex vivo culture.
[Journal of Clinical Investigation]
Chen, Y., Fang, S., Ding, Q., Jiang, R., He, J., Wang, Q., Jin, Y., Huang, X., Liu, S., Capitano, M., Trinh, T., Teng, Y., Meng, Q., Wan, J., Broxmeyer, H., & Guo, B. (2021). ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI148329 Cite
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