Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Postdoc Union Reaches Tentative Agreement with University of California

[Science Careers] After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.

Performance Assessment and Economic Analysis of a Human Liver-Chip for Predictive Toxicology

[Communications Medicine] 870 Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who has published guidelines defining criteria for qualifying preclinical models.

Dialysis Based-Culture Medium Conditioning Improved the Generation of Human Induced Pluripotent Stem Cell Derived-Liver Organoid in a High Cell Density

[Scientific Reports] Investigators developed a simple dialysis-based medium conditioning that fully utilized growth factors accumulation to improve hepatic differentiation of human iPSCs at a high cell density.

Extracellular Matrix Drives Tumor Organoids toward Desmoplastic Matrix Deposition and Mesenchymal Transition

[Acta Biomaterialia] The authors combined cholangiocarcinoma organoids with native tumor and liver scaffolds, obtained by decellularization, to effectuate a model to study the interaction between epithelial tumor cells and their surrounding ECM.

Matrix Viscoelasticity Controls Spatiotemporal Tissue Organization

[Nature Materials] Scientists showed that the passive viscoelastic properties of the matrix encapsulating a spheroidal tissue of breast epithelial cells guide tissue proliferation in space and in time.

Organoids of the Male Reproductive System: Challenges, Opportunities, and Their Potential Use in Fertility Research

[WIRES Mechanisms of Disease] The authors revise the current knowledge on organoid technology and its use in healthcare and research, describe the male reproductive system organoids and other biomaterials already developed, and discuss their current application.

BRAFV600E in Colorectal Cancer Reduces Sensitivity to Oxidative Stress and Promotes Site-Specific Metastasis by Stimulating Glutathione Synthesis

[Cell Reports] BRAFV600E tumors and PDOs express high levels of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis. Deletion of GCL in BRAFV600E PDOs strongly reduced their capacity to form distant liver and lung metastases but did not affect peritoneal metastasis outgrowth.

Vaginal Microbiome-Host Interactions Modeled in a Human Vagina-on-a-Chip

[Microbiome] Scientists describe an organ-on-a-chip microfluidic culture model of the human vaginal mucosa that was lined by hormone-sensitive, primary vaginal epithelium interfaced with underlying stromal fibroblasts, which sustained a low physiological oxygen concentration in the epithelial lumen.

Successful Engraftment of Bladder Organoids in De-Epithelialized Mouse Colon

[Seminars in Pediatric Surgery] Bladder organoids cultured using bladder specimens from enhanced green fluorescent protein transgenic mice were engrafted to replace proximal colon epithelium stripped from an approximately 1 cm long target site in syngeneic wild-type recipient mice by exposure to ethylenediaminetetraacetic acid by infusion and flushing with phosphate buffered saline.

Mother Cells Control Daughter Cell Proliferation in Intestinal Organoids to Minimize Proliferation Fluctuations

[eLife] Investigators used time-lapse microscopy to track all cells in crypts of growing mouse intestinal organoids for multiple generations, allowing full reconstruction of the underlying lineage dynamics in space and time.

Elevated FSP1 Protects KRAS-Mutated Cells from Ferroptosis during Tumor Initiation

[Cell Death & Differentiation] The authors found that pharmacological induction of ferroptosis in pancreatic organoids derived from the LsL-KRASG12D expressing mouse model was only effective in combination with FSP1 inhibition.

Collagen Type I-Mediated Mechanotransduction Controls Epithelial Cell Fate Conversion during Intestinal Inflammation

[Inflammation and Regeneration] Investigators performed microarray, RNA-seq, and ATAC-seq analyses of the murine collagen sphere in comparison with Matrigel organoid and fetal enterospher.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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