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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Progress in the Application of Organoids for Exploring the Relationship between Macrophages and Various Lung Diseases
[Biofabrication] Investigators summarize the research progress on organoids in exploring macrophage involvement in pulmonary diseases.
Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co-Culture System
[Cell Proliferation] Myocardium and nerve tissues were modelled by 3D engineered heart tissues and neural organoids, which were co-cultured in a generalised medium with normal or elevated glucose/fatty acid contents.
Gastruloids Enable Modeling of the Earliest Stages of Human Cardiac and Hepatic Vascularization
[Science] Researchers demonstrated that micropatterned hPSC–derived gastruloids enable in vitro modeling of the earliest stages of vascularization.
First Axiom Space-Tested Aspera Biomedicines Drug Advances Toward Clinical Trials
[Axiom Space] Rebecsinib, a therapeutic cancer drug that targets a cancer cloning and immune evasion gene, ADAR1, was tested during Axiom Mission 2 and 3 and is slated to be tested during Axiom Mission 4. The drug has received FDA approval to enter clinical trials under active Investigational New Drug status.
FXYD2 Marks and Regulates Maturity of β Cells via Ion Channel-Mediated Signal Transduction
[Nature Communications] Researchers showed that FXYD Domain Containing Ion Transport Regulator 2 (FXYD2) marks and regulates functional maturation and heterogeneity of generated human islet-like organoids, by controlling the β cell transcriptome necessary for glucose-stimulated insulin secretion.
Establishing 3D Organoid Models from Patient-Derived Conditionally Reprogrammed Cells to Bridge Preclinical and Clinical Insights in Pancreatic Cancer
[Molecular Cancer] The authors established 3D organoid cultures using patient-derived conditionally reprogrammed cell lines, originally cultured under 2D conditions.
Monitoring the Dynamics of Alzheimer’s Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno-SERS
[Advanced Science] The label-free and non-invasive detection of multiple tau variants dynamics across developmental stages, age-related variants, and various APOE isogenic genotyes was presented to investigate the APOE–tau axis using human cerebral organoids combined with surface-enhanced Raman spectroscopy (SERS).
HAMA-SBMA Hydrogel with Anti-Inflammatory Properties Delivers Cartilage Organoids, Boosting Cartilage Regeneration
[Journal of Nanobiotechnology] Investigators loaded allogeneic bone marrow mesenchymal stem cells onto decellularized extracellular matrix microparticles of porcine articular cartilage to construct cartilage organoids, which demonstrates characteristics of articular cartilage.
Matrix-Bound EGF Promotes Malignant Phenotypes of Breast Cancer Organoids in the Biomimetic ECM of Alginate
[Materials Today Bio] Scientists established in vitro 3D breast cancer organoid models in the recreating tumor-stroma niche by using alginate cryogels to mimic the porous extracellular matrix (ECM), especially to introduce the controlled release of matrix-bound growth factor epidermal growth factor (EGF).
3D Bioprinting for Engineering Organoids and Organ-on-a-Chip: Developments and Applications
[Medicinal Research Reviews] Investigators provide an overview of the fundamental techniques of 3D bioprinting and examines the benefits of utilizing this technology to develop organoid and organ-on-a-chip functional tissue models.
Organoid-Based Single Cell Sequencing Revealed the Lineage Evolution during Docetaxel Treatment in Gastric Cancer
[Cancer Letters] The authors established docetaxel-sensitive and -resistant gastric cancer organoids and performed single-cell RNA sequencing to identify cellular and molecular alterations.
Determinants of Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids
[mBio] Investigators followed Salmonella and Shigella infections of human enteroids and colonoids by time-lapse imaging to pinpoint virulence factor modules that shape the divergent epithelial colonization strategies.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
