[Scientific Reports] Researchers studied the effect of specific IgG2a mouse monoclonal antibodies targeting human C1s in five primary non-metastatic and three metastatic cutaneous squamous cell carcinoma cell lines that showed intracellular expression of C1s and secretion of C1s into the cell culture media.

[Diabetes] Investigators reported that STAT1 served as a substrate for HDAC6 in β-cells and that sequestration of HDAC6 by SIRPα in response to anti-inflammatory cytokines (such as interleukin-13) led to increased STAT1 acetylation.

[Molecular Therapy] Scientists demonstrated the presence of efferocytosis in injured human and mouse pancreatic tissues. They also observed significant upregulation of CD47, an efferocytosis-related "do not eat me" molecule, in injured acinar cells.

[Cell Stem Cell] Researchers integrated organoid and organ-on-a-chip technology to develop an advanced human organoid model, called “mini-colons.” By employing an asymmetric stimulation with growth factors, they greatly enhanced tissue longevity and replicated in vivo-like diversity and patterning of proliferative and differentiated cell types.

[Heliyon] The authors review the multiple components of NFκB signaling, highlighting that NFκB inducing kinase may be the central kinase for non-canonical NFκB signaling, and that IKKα is involved in novel pathways which promote colorectal cancer.

[Nature Medicine] Scientists reported results from a Phase II, first-in-human study of prostate stem cell antigen (PSCA)-directed CAR T cells in men with metastatic castration-resistant prostate cancer.

[Molecular Therapy-Methods & Clinical Development] Scientists explored the therapeutic potential of adeno-associated virus 9 (AAV9) mediated delivery of the FOXG1 gene. Remarkably, intracerebroventricular injection of AAV9-FOXG1 to Foxg1 heterozygous mouse model at the postnatal stage rescues a wide range of brain pathologies.

[Nature Communications] Researchers reported a synthetic biodegradable microporous hydrogel for efficient formation of 3D networks from human primary cells, analysis of cell-secreted ECM and microfluidic integration.

[Life Sciences] The authors evaluated whether the hydrogen sulfide (H2S) donor, 4-carboxyphenyl-isothiocyanate, exerted cardioprotective effect in the two kidney- one clip rats through oxidative stress and MMP-2 activity attenuation, and compared it with the classical H2S donor, Sodium Hydrosulfide.

[Journal of Nanobiotechnology] The in vivo investigation verified that long-term inhalation exposure to silica nanoparticles (SiNPs) induced fibroblast activation and collagen deposition in the rat lungs. In vitro, the uptake of exosomes derived from SiNPs-stimulated lung epithelial cells by fibroblasts enhanced its proliferation, adhesion, and activation.

[University of Arkansas] Younghye Song, assistant professor of biomedical engineering in the U of Arkansas's College of Engineering, has recently been awarded a $2.5 million National Institutes of Health R37 grant from the National Cancer Institute to investigate the role of metabolic rewiring in breast tumor innervation.

[Nature News] In the past year, cyberattacks have struck several research institutions in Germany and beyond. Most involve ransomware, in which data or systems are locked until a payment is made.