Keep Current with the Latest in Cell Biology Research

Switch of Macrophage Fusion Competency by 3D Matrices

Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports]
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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

Scientists showed in xenograft models that targeting diacylglycerol-acyltransferase 1 blocked lipid droplet formation, induced tumor cell apoptosis, and markedly suppressed glioblastoma growth.
[Cell Metabolism]
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Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury

Transplanted skin-derived precursors differentiated into Schwann cells (SCs) filled much of the lesion sites and greatly enhanced the presence of endogenous SCs, which myelinated thousands of sprouting/spared host axons in and around the injury site.
[Stem Cell Reports]
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The Stem Cell Marker Prom1 Promotes Axon Regeneration by Down-Regulating Cholesterol Synthesis via Smad Signaling

Elevating prominin-1 levels in cultured dorsal root ganglion neurons or in mice via adeno-associated virus-mediated gene delivery enhances axon regeneration in vitro and in vivo, allowing outgrowth on an inhibitory substrate.
[Proceedings of the National Academy of Sciences of the United States of America]
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Nolz1 Expression Is Required in Dopaminergic Axon Guidance and Striatal Innervation

Investigators demonstrated a striatal-specific requirement of transcriptional regulator Nolz1 in establishing dopaminergic circuitry formation.
[Nature Communications]
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Distinct Synchronization, Cortical Coupling and Behavioral Function of Two Basal Forebrain Cholinergic Neuron Types

Researchers recorded basal forebrain cholinergic neurons in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties.
[Nature Neuroscience]
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Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

Researchers introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
[Neuron]
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Reversing a Model of Parkinson’s Disease with In Situ Converted Nigral Neurons

Investigators report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB.
[Nature]
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Lysosomal Perturbations in Human Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells with PARK2 Mutation

PARK2 knockout neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondrial stress and could be ameliorated by antioxidant treatment.
[Scientific Reports]
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University of Kentucky, Children’s Hospital of Philadelphia and Mitochon Pharmaceuticals Awarded NIH Grant for Traumatic Brain Injury Studies

Mitochon Pharmaceuticals announced that they, in partnership with the University of Kentucky and Children’s Hospital of Philadelphia, were awarded a $3.2M National Institutes of Health grant to study Mitochon’s mitochondrial targeted drug therapies for treating traumatic brain injury.
[Mitochon Pharmaceuticals]
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Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

The authors present an overview of recent studies on the developmental origins, migratory properties, and morphology of chandelier cells.
[Trends in Neurosciences]
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