[Journal of Clinical Investigation] Using newly generated mouse models, researchers uncovered that cerebral endothelial cells (ECs) acquired mesenchymal markers and caused vascular malformations. They found that limiting endothelial histone deacetylase 2 prevented cerebral ECs from undergoing mesenchymal differentiation and reduced cerebral arteriovenous malformations.

[Biochemical Pharmacology] The authors review the pro-inflammatory role of IL-17A in diabetic retinopathy, with focus in how IL-17A impact inflammation and angiogenesis crosstalk.

[Biopharmadealmakers] For centuries, women’s health has been neglected across science, medicine and technology. A new report from the World Economic Forum suggests tackling this could unlock a $1 trillion economic boost with the potential to change the lives of 3.9 billion women.

[Bone Research] Scientists showed that transplantation of fecal microbiota of collagen-induced arthritis (CIA)-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice. C57BL/6J mice and healthy human individuals have enriched B. fragilis than DBA/1J mice and rheumatoid arthritis patients.

[Circulation Research] The authors explore the current state of knowledge in HIV and cardiovascular disease, exploring risk factors, therapies, and future research directions.

[Science Advances] Researchers collected para-cancerous cervical tissues from patients diagnosed with cervical squamous cell carcinoma (CSCC) and prepared uterine cervix extracellular matrix (UCEM) hydrogels. UCEM provided a tailored microenvironment for CSCC organoids, enabling formation and growth while preserving tumorigenic potential.

[TheScientist] Herpetology meets hepatology as scientists develop new tools for exploring how turtles survive freezing, oxygen-poor environments.

[Journal For Immunotherapy of Cancer] circPOLQ entered macrophages via colorectal cancer (CRC) cell-derived exosomes and promoted CRC metastatic nodule formation by enhancing M2 macrophage polarization. These findings revealed a tumor-derived exosome-mediated tumor–macrophage interaction potentially affecting CRC metastatic nodule formation.

[Journal For Immunotherapy of Cancer] To enhance neutrophil cytotoxicity, IgG ch14.18 was converted to the IgA isotype, resulting in potent neutrophil-mediated antibody-dependent cell-mediated cytotoxicity, without complement activation.

[Journal of Experimental Medicine] Scientists implicated the UNC93B1-TLR7/8 axis in human monogenic autoimmune diseases and provided a functional resource to assess the impact of yet-to-be-reported UNC93B1 mutations.

[Cellular and Molecular Life Sciences] Using mass spectrometry combined with co-immunoprecipitation, researchers identified optic atrophy 1 (OPA1) interacting with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3).

[Signal Transduction and Targeted Therapy] Scientists generated cardiomyocyte-specific Ddx17-knockout mice, cardiomyocyte-specific Ddx17 transgenic mice (Ddx17-Tg), and various models of cardiomyocyte injury and heart failure.