[Anova Enterprises, Inc.] Anova Enterprises, Inc. has collaborated with University of California at San Francisco, University of California at San Diego, University of Southern California, and Denovo Biopharma to manage a newly awarded $11.8M California Institute for Regenerative Medicine (CIRM) grant to support the development of DB107 in patients with newly diagnosed high-grade glioma.

[Advanced Materials] Investigators developed pathogenic tau-specific autophagy based on customized nanochaperone for Alzheimer’s disease treatment.

[Science Advances] Scientists designed a seven-residue D-TLKIVWC peptide, which not only prevented tau aggregation but also fragmented tau fibrils extracted from Alzheimer’s disease brains to neutralize their seeding ability and protect neuronal cells from tau-induced toxicity.

[Overseas Community Affairs Council, Republic of China] Executive Yuan approved the Ministry of Health and Welfare's draft bills for a regenerative medicine act and a regenerative pharmaceuticals act.

[Cell Reports] Investigators showed that the Mediator Med23 was critically important for muscle stem cell (MuSC)-mediated muscle regeneration. Med23 was increasingly expressed in activated/proliferating MuSCs on isolated myofibers or in response to muscle injury.

[Circulation] The authors used smooth muscle cell (SMC) lineage tracing mice and human tissues and applied a range of methods, including molecular, cellular, histological, computational, human genetics, and pharmacological approaches, to investigate the features of SMC-derived cells in atherosclerosis.

[Annals Of Hematology] Investigators outline the basic biology characteristics of HSCs, and focus on the regulatory factors in bone marrow niche affecting the functions of HSCs.

[Advanced Science] A system was described for differentiating hiPSCs on new generation laminin fragments, a recombinant form of a laminin E8 fragment conjugated to the heparan sulfate chains attachment domain of perlecan.

[iScience] Given that the equivalence of hESCs and hiPSCs remained controversial, investigators sought to compare the molecular and functional equivalence of hESC- and hiPSC-derived Schwann cells generated with a previously reported protocol.

[Cell] Scientists constructed a 3D model of the CS8 embryo, in which a range of cell subtypes were identified, based on gene expression patterns and positional register, along the anterior-posterior, medial-lateral, and dorsal-ventral axis in the embryo.

[Development] The authors showed that Entropy Sorting provided an alternative mathematical framework for feature selection. On synthetic datasets, continuous entropy sort feature weighting outperformed highly variable gene selection in distinguishing cell state specific genes.

[Cell Death Discovery] Researchers identified the oncogenic protein annexin 2 (ANXA2) as a potential interacting patterner of highly accelerated region 1A (HAR1A). HAR1A overexpression enhanced ANXA2 ubiquitination and accelerated its degradation via the ubiquitin–proteasome pathway.