Keep Current with the Latest in Cell Biology Research

Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation during the Skin Wound Healing Process

Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
[Cells]
Kim, D.-W., Choi, C.-H., Park, J. P., & Lee, S.-J. (2020). Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation During the Skin Wound Healing Process. Cells, 9(6), 1467. https://doi.org/10.3390/cells9061467 Cite
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miR-410-3p Is Induced by Vemurafenib via ER Stress and Contributes to Resistance to BRAF Inhibitor in Melanoma

Scientists showed a novel mechanism of melanoma resistance. miR-410-3p was induced by vemurafenib in melanoma cells via ER stress. It drove switching to the invasive phenotype that led to the response and resistance to BRAF inhibition.
[PLoS One]
Grzywa, T. M., Klicka, K., Paskal, W., Dudkiewicz, J., Wejman, J., Pyzlak, M., & Włodarski, P. K. (2020). miR-410-3p is induced by vemurafenib via ER stress and contributes to resistance to BRAF inhibitor in melanoma. PLOS ONE, 15(6), e0234707. https://doi.org/10.1371/journal.pone.0234707 Cite
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Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts

The authors investigated the potential anticancer effect of Abeliophyllum distichum organ extracts against human melanoma SK-MEL-2 cells. The methanol extract of A. distichum leaves exhibited dose- and time-dependent cytotoxicities against SK-MEL-2 cells but not against HDFa human dermal fibroblasts.
[Plants ]
Yoo, T.-K., Kim, J.-S., & Hyun, T. K. (2020). Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts. Plants, 9(6), 757. https://doi.org/10.3390/plants9060757 Cite
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Andrographis paniculata and Its Bioactive Diterpenoids against Inflammation and Oxidative Stress in Keratinocytes

Investigators showed a decrease in reactive oxygen species production and tumor necrosis factor-α expression by methanolic extract (ME) in HaCaT under pro-oxidant and pro-inflammatory conditions, respectively. ME protected HaCaT against oxidative stress and inflammation.
[Antioxidants]
Mussard, E., Jousselin, S., Cesaro, A., Legrain, B., Lespessailles, E., Esteve, E., Berteina-Raboin, S., & Toumi, H. (2020). Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. Antioxidants, 9(6), 530. https://doi.org/10.3390/antiox9060530 Cite
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Arcutis Enrolls Last Patient in Phase II Proof of Concept Clinical Trial Evaluating ARQ-154 (Topical Roflumilast Foam) as a Potential Treatment for Seborrheic Dermatitis

Arcutis Biotherapeutics, Inc. announced it has completed enrollment of its Phase II proof of concept clinical trial evaluating roflumilast foam as a potential treatment for seborrheic dermatitis.
[Arcutis Biotherapeutics]
Press Release
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Dupixent® (Dupilumab) Approved in China for Adults with Moderate-to-Severe Atopic Dermatitis

The National Medical Products Administration in China has approved Dupixent® for the treatment of moderate-to-severe atopic dermatitis in adults whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
[Sanofi]
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]
Du, J., Xu, Y., Sasada, S., Oo, A. K. K., Hassan, G., Mahmud, H., Khayrani, A. C., Alam, M. J., Kumon, K., Uesaki, R., Afify, S. M., Mansour, H. M., Nair, N., Zahra, M. H., Seno, A., Okada, N., Chen, L., Yan, T., & Seno, M. (2020). Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment. Scientific Reports, 10(1), 9955. https://doi.org/10.1038/s41598-020-66471-2 Cite
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Derivation of Oocyte-Like Cells from Putative Embryonic Stem Cells and Parthenogenetically Activated into Blastocysts in Goat

Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
[Scientific Reports]
Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat | Scientific Reports. (n.d.). Retrieved June 22, 2020, from https://www.nature.com/articles/s41598-020-66609-2 Cite
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Multi-Omic Analysis Reveals Significantly Mutated Genes and DDX3X as a Sex-Specific Tumor Suppressor in Cutaneous Melanoma

Researchers performed a mutation significance study of over 1,000 melanoma exomes, combined with a multi-omic analysis of 470 cases from The Cancer Genome Atlas.
[Nature Cancer]
Alkallas, R., Lajoie, M., Moldoveanu, D., Hoang, K. V., Lefrançois, P., Lingrand, M., Ahanfeshar-Adams, M., Watters, K., Spatz, A., Zippin, J. H., Najafabadi, H. S., & Watson, I. R. (2020). Multi-omic analysis reveals significantly mutated genes and DDX3X as a sex-specific tumor suppressor in cutaneous melanoma. Nature Cancer, 1(6), 635–652. https://doi.org/10.1038/s43018-020-0077-8 Cite
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Epigenetic Priming by Dppa2 and 4 in Pluripotency Facilitates Multi-Lineage Commitment

Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology]
Eckersley-Maslin, M. A., Parry, A., Blotenburg, M., Krueger, C., Ito, Y., Franklin, V. N. R., Narita, M., D’Santos, C. S., & Reik, W. (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural & Molecular Biology, 1–10. https://doi.org/10.1038/s41594-020-0443-3 Cite
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Clonally Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping Efferocytosis and Activating the Complement Cascade

Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., Howe, K. L., Jarr, K.-U., Flores, A. M., Tsantilas, P., Tsao, N., Rao, A., Newman, A. A. C., Eberhard, A. V., Priest, J. R., Ruusalepp, A., Pasterkamp, G., Maegdefessel, L., Miller, C. L., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006348117 Cite
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