Keep Current with the Latest in Cell Biology Research
Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
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Scientists showed a novel mechanism of melanoma resistance. miR-410-3p was induced by vemurafenib in melanoma cells via ER stress. It drove switching to the invasive phenotype that led to the response and resistance to BRAF inhibition.
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The authors investigated the potential anticancer effect of Abeliophyllum distichum organ extracts against human melanoma SK-MEL-2 cells. The methanol extract of A. distichum leaves exhibited dose- and time-dependent cytotoxicities against SK-MEL-2 cells but not against HDFa human dermal fibroblasts.
Investigators showed a decrease in reactive oxygen species production and tumor necrosis factor-α expression by methanolic extract (ME) in HaCaT under pro-oxidant and pro-inflammatory conditions, respectively. ME protected HaCaT against oxidative stress and inflammation.
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Mussard, E., Jousselin, S., Cesaro, A., Legrain, B., Lespessailles, E., Esteve, E., Berteina-Raboin, S., & Toumi, H. (2020). Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. Antioxidants, 9(6), 530. https://doi.org/10.3390/antiox9060530 Cite
Arcutis Biotherapeutics, Inc. announced it has completed enrollment of its Phase II proof of concept clinical trial evaluating roflumilast foam as a potential treatment for seborrheic dermatitis.
The National Medical Products Administration in China has approved Dupixent® for the treatment of moderate-to-severe atopic dermatitis in adults whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
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Du, J., Xu, Y., Sasada, S., Oo, A. K. K., Hassan, G., Mahmud, H., Khayrani, A. C., Alam, M. J., Kumon, K., Uesaki, R., Afify, S. M., Mansour, H. M., Nair, N., Zahra, M. H., Seno, A., Okada, N., Chen, L., Yan, T., & Seno, M. (2020). Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment. Scientific Reports, 10(1), 9955. https://doi.org/10.1038/s41598-020-66471-2 Cite
Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
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Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat | Scientific Reports. (n.d.). Retrieved June 22, 2020, from https://www.nature.com/articles/s41598-020-66609-2 Cite
Researchers performed a mutation significance study of over 1,000 melanoma exomes, combined with a multi-omic analysis of 470 cases from The Cancer Genome Atlas.
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Alkallas, R., Lajoie, M., Moldoveanu, D., Hoang, K. V., Lefrançois, P., Lingrand, M., Ahanfeshar-Adams, M., Watters, K., Spatz, A., Zippin, J. H., Najafabadi, H. S., & Watson, I. R. (2020). Multi-omic analysis reveals significantly mutated genes and DDX3X as a sex-specific tumor suppressor in cutaneous melanoma. Nature Cancer, 1(6), 635–652. https://doi.org/10.1038/s43018-020-0077-8 Cite
Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology]
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Eckersley-Maslin, M. A., Parry, A., Blotenburg, M., Krueger, C., Ito, Y., Franklin, V. N. R., Narita, M., D’Santos, C. S., & Reik, W. (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural & Molecular Biology, 1–10. https://doi.org/10.1038/s41594-020-0443-3 Cite
Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
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Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., Howe, K. L., Jarr, K.-U., Flores, A. M., Tsantilas, P., Tsao, N., Rao, A., Newman, A. A. C., Eberhard, A. V., Priest, J. R., Ruusalepp, A., Pasterkamp, G., Maegdefessel, L., Miller, C. L., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006348117 Cite