AKT

[Advanced Healthcare Materials] Researchers used a recently developed composite hydrogel composed of a fibrin matrix and phase-shift emulsion, termed an acoustically-responsive scaffold, to investigate effects of local mechanical properties on breast cancer cell signaling.

[npj Systems Biology and Applications] The authors used in vitro models to evaluate the transcriptional changes due to the presence of CTCFL, followed by a selection of gene candidates using de novo network enrichment analysis.

[iScience] The authors found that Reh acute lymphoblastic leukemia cells bearing the KRAS-G12D mutation showed increased proliferation rates in vitro but displayed severely compromised growth in mice.

[Cell Death & Disease] Scientists assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of soluble CD74 in melanoma.

[Cancer Cell International] Investigators compared the transcriptomes of nine canine cell lines derived from prostate adenocarcinoma (PAC), PAC metastasis and transitional cell carcinoma to their respective original primary tumor or metastasis tissues.

[Science Advances] eEF-2K KO CD8+ T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway.