AKT

[Cell Death & Disease] Researchers reported that nerve growth factor (NGF) facilitated lysyl oxidase-dependent cellular migration and invasion in human chondrosarcoma cells, and that NGF overexpression enhanced lung metastasis in a mouse model of chondrosarcoma.

[Experimental Cell Research] Scientists review the roles and behaviors of muscle satellite cells, characteristics of new myonuclei in muscle hypertrophy, and their relevance to sarcopenia.

[Cell Death & Disease] In vitro data on C2C12 cells showed that TNF-related apoptosis-inducing ligand (TRAIL) treatment significantly increased myogenin and MyHC and other hallmarks of myogenic differentiation, which were reduced by Dr5 (TRAIL receptor) silencing.

[Acta Pharmacologica Sinica] The authors demonstrated that 5-(4-hydroxyphenyl)−3H-1,2-dithiocyclopentene-3-thione (ADT-OH) inhibited the EMT process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity.

[Science Advances] Overexpression of C1q/TNF-related protein-3 (CTRP3) enhanced the progression of tendinopathy by accumulating cartilaginous proteoglycans and degenerating collagenous fibers in the mouse tendon, whereas CTRP3 knockdown suppressed the tendinopathy pathogenesis.

[Archives of Pharmacal Research] Scientists provided important evidence that kaempferol targeting RSKs might be a strategy to reduce the oxaliplatin-resistant colon cancer cells.