AKT

[Scientific Reports] Scientists investigated the relationship between the expression of EZH1/2 and the level of histone H3 Lysine 27 trimethylation in hepatocellular carcinoma.

[Cell Communication and Signaling] A dystrophin-deficient myoblast cell line established from the skeletal muscle of a dystrophic mouse was used as a model. The dfd13 and C2C12 myoblasts were cultured in low mitogen conditions for ten days to induce differentiation.

[Cell Death & Disease] The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.

[Phytotherapy Research] Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.

[Neoplasia] Scientists discovered that brain-type creatine kinase (CKB) was a negative regulator of epithelial-mesenchymal transition and AKT activation, which revealed a new mode of their regulation.

[Cell Death & Disease] Investigators confirmed that BEZ235 could suppress the proliferation, invasion and colony conformation abilities of intrahepatic cholangiocarcinoma (ICC) cells in vitro but could not effectively inhibit ICC progression in vivo.