AKT

[Cancer Gene Therapy] Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.

[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.

[Oncogene] In vitro experiments showed that a subset of combination therapy melanoma cells was sensitive to mTORC1 inhibition.

[Cell Biochemistry and Biophysics] Scientists showed that treatment with burn serum could significantly upregulate the phosphorylation level of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase and the expression of cleaved caspase-3 and downregulated the expression of Bcl2 when compared with those in negative control of small interfering RNA transfected H9C2 cells

[Journal of Materials Chemistry B] Scientists showed that the Platelet derived growth factor-BB (PDGF-BB)/sodium alginate (SA)/dextran (Dex) hydrogels could sustainably release PDGF-BB with excellent biocompatibility in vitro and in vivo.

[Gene] To better characterize the molecular genetic events of atrophy, a microarray analysis revealed that FGGY carbohydrate kinase domain containing was expressed in skeletal muscle and was induced in response to denervation.