AKT

[EMBO Molecular Medicine] The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.

[Nature Communications] Mechanistically, WSX1 transcriptionally downregulated an isoform of PI3K—PI3Kδ and thereby inactivated AKT, reducing AKT-induced GSK3β inhibition.

[Free Radical Biology and Medicine] Researchers explored anti-prostate cancer activity in a polyphenol-rich fraction of Bergenia ligulata, a plant used in Indian traditional and folk medicine for its anti-inflammatory and antineoplastic properties.

[Nature Communications] Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.

[Scientific Reports] Investigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.

[Blood] Researchers reveal oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm, Erdheim-Chester disease, characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production.