Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsInvestigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.
[Scientific Reports]
7753456 8MZF2UWG items 1 apa 0 default asc 1 163064 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d91863b789ce494e831bf62b1dc8ea50%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228MZF2UWG%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zbodakova%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZbodakova%2C%20O.%2C%20Chalupsky%2C%20K.%2C%20Sarnova%2C%20L.%2C%20Kasparek%2C%20P.%2C%20Jirouskova%2C%20M.%2C%20Gregor%2C%20M.%2C%20%26amp%3B%20Sedlacek%2C%20R.%20%282021%29.%20ADAM10%20and%20ADAM17%20regulate%20EGFR%2C%20c-Met%20and%20TNF%20RI%20signalling%20in%20liver%20regeneration%20and%20fibrosis.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2011414.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-90716-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-90716-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D8MZF2UWG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ADAM10%20and%20ADAM17%20regulate%20EGFR%2C%20c-Met%20and%20TNF%20RI%20signalling%20in%20liver%20regeneration%20and%20fibrosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Zbodakova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karel%22%2C%22lastName%22%3A%22Chalupsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lenka%22%2C%22lastName%22%3A%22Sarnova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petr%22%2C%22lastName%22%3A%22Kasparek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marketa%22%2C%22lastName%22%3A%22Jirouskova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Gregor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Radislav%22%2C%22lastName%22%3A%22Sedlacek%22%7D%5D%2C%22abstractNote%22%3A%22ADAM10%20and%20ADAM17%20are%20proteases%20that%20affect%20multiple%20signalling%20pathways%20by%20releasing%20molecules%20from%20the%20cell%20surface.%20As%20their%20substrate%20specificities%20partially%20overlaps%2C%20we%20investigated%20their%20concurrent%20role%20in%20liver%20regeneration%20and%20fibrosis%2C%20using%20three%20liver-specific%20deficient%20mouse%20lines%3A%20ADAM10-%20and%20ADAM17-deficient%20lines%2C%20and%20a%20line%20deficient%20for%20both%20proteases.%20In%20the%20model%20of%20partial%20hepatectomy%2C%20double%20deficient%20mice%20exhibited%20decreased%20AKT%20phosphorylation%2C%20decreased%20release%20of%20EGFR%20activating%20factors%20and%20lower%20shedding%20of%20HGF%20receptor%20c-Met.%20Thus%2C%20simultaneous%20ablation%20of%20ADAM10%20and%20ADAM17%20resulted%20in%20inhibited%20EGFR%20signalling%2C%20while%20HGF%5C%2Fc-Met%20signalling%20pathway%20was%20enhanced.%20In%20contrast%2C%20antagonistic%20effects%20of%20ADAM10%20and%20ADAM17%20were%20observed%20in%20the%20model%20of%20chronic%20CCl4%20intoxication.%20While%20ADAM10-deficient%20mice%20develop%20more%20severe%20fibrosis%20manifested%20by%20high%20ALT%2C%20AST%2C%20ALP%20and%20higher%20collagen%20deposition%2C%20combined%20deficiency%20of%20ADAM10%20and%20ADAM17%20surprisingly%20results%20in%20comparable%20degree%20of%20liver%20damage%20as%20in%20control%20littermates.%20Therefore%2C%20ADAM17%20deficiency%20is%20not%20protective%20in%20fibrosis%20development%20per%20se%2C%20but%20can%20ameliorate%20the%20damaging%20effect%20of%20ADAM10%20deficiency%20on%20liver%20fibrosis%20development.%20Furthermore%2C%20we%20show%20that%20while%20ablation%20of%20ADAM17%20resulted%20in%20decreased%20shedding%20of%20TNF%20RI%2C%20ADAM10%20deficiency%20leads%20to%20increased%20levels%20of%20soluble%20TNF%20RI%20in%20serum.%20In%20conclusion%2C%20hepatocyte-derived%20ADAM10%20and%20ADAM17%20are%20important%20regulators%20of%20growth%20receptor%20signalling%20and%20TNF%20RI%20release%2C%20and%20pathological%20roles%20of%20these%20proteases%20are%20dependent%20on%20the%20cellular%20context.%22%2C%22date%22%3A%222021-06-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-90716-3%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-90716-3%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22NTMX856R%22%5D%2C%22dateModified%22%3A%222021-06-01T20%3A52%3A14Z%22%7D%7D%5D%7D
Zbodakova, O., Chalupsky, K., Sarnova, L., Kasparek, P., Jirouskova, M., Gregor, M., & Sedlacek, R. (2021). ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Scientific Reports, 11(1), 11414. https://doi.org/10.1038/s41598-021-90716-3 Cite
