AKT

[Cancer Letters] Researchers investigated the interaction of ras-related protein in brain (Rab8A) and tropomyosin-related kinase B in regulating the progression of breast cancer. Rab8A was upregulated in breast cancer tissues.

[Scientific Reports] The authors investigated the relationship amongst PTEN deletion, L-asparaginase sensitivity and glucose metabolism in T cell acute lymphoblastic leukemia cells.

[International Immunopharmacology] The authors investigated the effects of S1P receptor 1 (S1P1) specific S1P analogue SEW2871, S1P1 and S1P5 specific BAF312, and non-selective FTY720 on human Th17 and Treg differentiation and IL-23-mediated signaling.

[Bioscience Reports] Scientists showed that alanine serine cysteine‑preferring transporter 2 (ASCT2) expression was significantly higher in pancreatic cancer than in normal pancreatic duct cells and pancreas.

[Toxicology and Applied Pharmacology] A series of cellular functional assays demonstrated that gastric carcinoma cells with silenced NUDT5 exhibited decreased proliferative and invasive ability, increased cell cycle arrest at the G0/G1 phase, and enhanced chemosensitivity.

[Molecular and Cellular Endocrinology] The authors investigated if ghrelin pretreatment enhanced the protective effect of bone marrow-derived mesenchymal stem cells-conditioned medium on lipopolysaccharide-induced endothelial cell injury.