AMPK

[Pharmacological Research] The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.

[European Journal of Pharmacology] While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.

[Experimental & Molecular Medicine] Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells.

[Biomedicine & Pharmacotherapy] Scientists examined PMI-5011 activation of AMP-activated protein kinase (AMPK) signaling using murine C2C12 muscle cell culture and skeletal muscle tissue.

[Environmental Toxicology] Researchers studied the regulatory effects of the PPARα agonist fibrate on the regulation of HIF-1α expression and its downstream target protein in glioblastoma.

[Acta Pharmacologica Sinica] Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.