Melatonin and Doxorubicin Synergistically Enhance Apoptosis via Autophagy-Dependent Reduction of AMPKα1 Transcription in Human Breast Cancer Cells

Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells.