Alzheimer's disease

[Life Sciences] After induction of the Alzheimer's disease model, the rats were transplanted with deferoxamine-preconditioned adipose-derived mesenchymal stem cells or untreated cells.

[Scientific Reports] Scientists identified Alzheimer's disease (AD)-associated layer-specific differences involving protein-coding and non-coding sequences, most of those present in the subcortical white matter, thus indicating a critical role for long axons and oligodendrocytes in AD pathomechanism.

[Heliyon] The possible roles of human umbilical mesenchymal stromal cord and adipose mesenchymal stem cells in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer's disease rat model.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Scientific Reports] Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs.

[Scientific Reports] Investigators established an in vitro cellular model using neurons differentiated from Down syndrome (DS) patient-derived iPSCs and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more amyloid β compared to those differentiated from the euploid iPSCs.