N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

Investigators established an in vitro cellular model using neurons differentiated from Down syndrome (DS) patient-derived iPSCs and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more amyloid β compared to those differentiated from the euploid iPSCs.