Axin2

[Cell Reports] Investigators reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative capacity.

[Scientific Reports] The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.

[Scientific Reports] Scientists analyzed data from The Cancer Genome Atlas to compare clinical phenotypes, somatic mutations, copy number variations, gene fusions, RNA expression, and DNA methylation profiles between APCmut– and APC mutation-positive (APCmut+) microsatellite stable colorectal cancer cells.

[Cell Death & Disease] Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.

[Journal of Molecular Neuroscience] After stimulation with Zeb2/Axin2-enriched BMSC exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.

[Cell Stem Cell] Researchers showed that restricted chromatin accessibility in intestinal stem cells prevented the expression of β-Catenin-regulated metabolic enzymes, whereas fine-tuning of WNT/β-Catenin activity by ZNRF3 and RNF43 restricted proliferation in chromatin-permissive AXIN2+ hepatocytes, while preserving metabolic function.