B cells

[Science] Given the well-established role of CD4 T cells in sustaining germinal centers (GCs) and the emerging role of Foxp3 in suppressing this reaction, scientists sought to determine whether expression of Foxp3 by GC-resident T cells could also play a role in GC longevity.

[Leukemia] In this open-label, single-arm Phase I/II trial, 87 patients with recurrent/refractory non-Hodgkin lymphoma received an infusion at doses of 0.5 × 106–8 × 106 TanCAR7 T cells per kilogram of body weight after conditioning chemotherapy.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers leveraged human epidermal-growth-factor receptor-2 (HER2) overexpression to engage antibody-dependent cellular phagocytosis through a combination of trastuzumab and anti-CD47 macrophage checkpoint immunotherapy.

[Journal of Pathology] The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.

[Cell Reports] Researchers demonstrated the ssDNA state in the 23 bp E2A fragile zone using several methods, including native bisulfite DNA structural analysis in live human pre-B cells.

[Cell Reports] While investigating B cell subsets among individuals recently infected with HIV, the authors observe an accumulation of CD27−CD38+ B cells and find that these cells can directly facilitate HIV infection of primary CD4+ T cells in vitro.