BDNF

[Scientific Reports] Scientists provided a comprehensive analysis of BDNF localization in rat skeletal muscle.

[Acta Biomaterialia] The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.

[Stem Cells International] Investigators manufactured neprilysin gene-enhanced human umbilical cord-derived MSCs and intravenously transplanted them in Aβ1-42-injected Alzheimer’s disease animal models.

[Translational Psychiatry] A post-stroke depression (PSD)-like model was established by treating neuronal cells with oxygen-glucose deprivation and corticosterone. Scientists found that protein pro-brain-derived neurotrophic factor (BDNF) levels were higher in the cortex and hippocampus in the PSD group than in the controls.

[PLoS One] Brain-derived neurotrophic factor promoted hematopoietic regeneration via activation of PDGFRα+ bone marrow MSCs which increased secretion of hematopoietic cytokines interleukin 6 and leukemia inhibitory factor in response to TrkB activation.

[Communications Biology] Scientists demonstrated that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor into active prodomain and mature BDNF for synaptic re-use.