BDNF

[Acta Pharmacologica Sinica] Researchers showed that sulforaphane confered stress resilience via brain-derived neurotrophic factor upregulation and changes in abnormal dendritic spine morphology in stressed mice, which was accompanied by rectifying the irregular levels of inflammatory cytokines.

[Journal of Cellular Physiology] Investigators found that glial cell-derived neurotrophic factor (GDNF) was expressed in human lung and increased in adult asthma, while human airway smooth muscle (ASM) expresses GDNF and its receptors. They used human ASM cells to test the hypothesis that ASM expression and autocrine signaling by GDNF family of ligands regulated [Ca2+]i.

[Carcinogenesis] The expression of Inhibitor of DNA binding and cell differentiation 4 (ID4), but not other ID family proteins, was enriched in LGR5-high colon cancer stem cells.

[npj Parkinson's Disease] The authors reiterate the merit of using the α-syn preformed fibril model as a tool to understand the physiological changes associated with Lewy bodies, while highlighting the neuroprotective potential of harnessing endogenous brain-derived neurotrophic factor.

[Human Cell] Considering the fact that neurotrophins and their receptors play crucial roles in neural differentiation of ESCs, investigators sought to evaluate whether knockdown of Fndc5 decreased neural differentiation of mESCs by affecting the neurotrophins and their receptors expression.

[Science Translational Medicine] To hasten treatment development, researchers established iPSC lines from patients with Christianson syndrome representing a mutational spectrum, as well as biologically related and isogenic control lines.