PB01 Suppresses Radio-Resistance by Regulating ATR Signaling in Human Non-Small-Cell Lung Cancer Cells

Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
[Scientific Reports]
Kim, T. W., Hong, D.-W., & Hong, S. H. (2021). PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells. Scientific Reports, 11(1), 12093. https://doi.org/10.1038/s41598-021-91716-z Cite
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Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten

Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
[Biochemical Genetics]
Cheng, M., Guo, Y., Zhong, W., Chen, X., & Guo, G. (2021). Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10083-6 Cite
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Microarray Analysis Reveals ONC201 Mediated Differential Mechanisms of Chop Gene Regulation in Metastatic and Nonmetastatic Colorectal Cancer Cells

The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
[Scientific Reports]
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Elevated GIGYF2 Expression Suppresses Tumor Migration and Enhances Sensitivity to Temozolomide in Malignant Glioma

Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.
[Cancer Gene Therapy]
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Antrodia salmonea Induces Apoptosis and Enhances Cytoprotective Autophagy in Colon Cancer Cells

Scientists explored the anti-cancer activity of Antrodia salmonea (AS) in colon cancer cells.MTT assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells
[Aging-Us]
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FLT3 Tyrosine Kinase Inhibitors Synergize with BCL-2 Inhibition to Eliminate FLT3/ITD Acute Leukemia Cells through BIM Activation

Scientists investigated the combination of FLT3 tyrosine kinase inhibitors (TKIs) with other drugs, and found that the combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary acute myeloid leukemia samples.
[Signal Transduction and Targeted Therapy]
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Phytochemicals from Ajwa Dates Pulp Extract Induce Apoptosis in Human Triple-Negative Breast Cancer by Inhibiting AKT/mTOR Pathway and Modulating Bcl-2 Family Proteins

Researchers analyzed the phytoconstituents in ethanolic Ajwa Dates Pulp Extract by liquid chromatography-mass spectrometry and investigated anticancer effects against MDA-MB-231 cells.
[Scientific Reports]
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UVB Protective Effects of Sargassum horneri through the Regulation of Nrf2 Mediated Antioxidant Mechanism

Scientists aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism.
[Scientific Reports]
Han, E. J., Kim, S.-Y., Han, H.-J., Kim, H.-S., Kim, K.-N., Fernando, I. P. S., Madusanka, D. M. D., Dias, M. K. H. M., Cheong, S. H., Park, S. R., Han, Y. S., Lee, K., & Ahn, G. (2021). UVB protective effects of Sargassum horneri through the regulation of Nrf2 mediated antioxidant mechanism. Scientific Reports, 11(1), 9963. https://doi.org/10.1038/s41598-021-88949-3 Cite
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Blueberry-Derived Exosomes-Like Nanoparticles Ameliorate Nonalcoholic Fatty Liver Disease by Attenuating Mitochondrial Oxidative Stress

Investigators found that blueberry-derived exosomes-like nanoparticles (BELNs) could ameliorate oxidative stress in rotenone-induced HepG2 cells and high-fat diet (HFD)-fed C57BL/6 mice.
[Acta Pharmacologica Sinica]
Zhao, W., Bian, Y., Wang, Q., Yin, F., Yin, L., Zhang, Y., & Liu, J. (2021). Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. Acta Pharmacologica Sinica, 1–14. https://doi.org/10.1038/s41401-021-00681-w Cite
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Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines

The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
Ebrahimi, M., Babaei, E., Neri, F., & Feizi, M. A. H. (2021). Anti-proliferative and apoptotic effect of gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics, 601, 120592. https://doi.org/10.1016/j.ijpharm.2021.120592 Cite
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β-Elemonic Acid Inhibits Growth and Triggers Apoptosis in Human Castration-Resistant Prostate Cancer Cells through the Suppression of JAK2/STAT3/MCL-1 and NF-ĸB Signal Pathways

The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer.
[Chemico-Biological Interactions]
Bao, X., Zhu, J., Ren, C., Zhao, A., Zhang, M., Zhu, Z., Lu, X., Zhang, Y., Li, X., Sima, X., Li, J., Zhang, Q., & Ma, B. (2021). β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-Biological Interactions, 109477. https://doi.org/10.1016/j.cbi.2021.109477 Cite
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