Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
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The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
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Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.
[Cancer Gene Therapy]
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Scientists explored the anti-cancer activity of Antrodia salmonea (AS) in colon cancer cells.MTT assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells
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Scientists investigated the combination of FLT3 tyrosine kinase inhibitors (TKIs) with other drugs, and found that the combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary acute myeloid leukemia samples.
[Signal Transduction and Targeted Therapy]
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Researchers analyzed the phytoconstituents in ethanolic Ajwa Dates Pulp Extract by liquid chromatography-mass spectrometry and investigated anticancer effects against MDA-MB-231 cells.
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Scientists aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism.
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Han, E. J., Kim, S.-Y., Han, H.-J., Kim, H.-S., Kim, K.-N., Fernando, I. P. S., Madusanka, D. M. D., Dias, M. K. H. M., Cheong, S. H., Park, S. R., Han, Y. S., Lee, K., & Ahn, G. (2021). UVB protective effects of Sargassum horneri through the regulation of Nrf2 mediated antioxidant mechanism. Scientific Reports, 11(1), 9963. https://doi.org/10.1038/s41598-021-88949-3 Cite
Investigators found that blueberry-derived exosomes-like nanoparticles (BELNs) could ameliorate oxidative stress in rotenone-induced HepG2 cells and high-fat diet (HFD)-fed C57BL/6 mice.
[Acta Pharmacologica Sinica]
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The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
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The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer.
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Bao, X., Zhu, J., Ren, C., Zhao, A., Zhang, M., Zhu, Z., Lu, X., Zhang, Y., Li, X., Sima, X., Li, J., Zhang, Q., & Ma, B. (2021). β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-Biological Interactions, 109477. https://doi.org/10.1016/j.cbi.2021.109477 Cite