Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells

Scientists investigated the cellular activities of α-mangostin, human cancer cells, MCF-7 and MCF-7-CR cells, by treating them with α-mangostin to measure the cellular responses, including cytotoxicity, protein-protein interaction, and protein expression.
[Evidence-Based Complementary and Alternative Medicine]
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Antiproliferative and Proapoptotic Activities of Sea Cucumber H. Leucospilota Extract on Breast Carcinoma Cell Line (SK-BR-3)

H. leucospilota was collected, the methanolic extract was prepared and in vitro cytotoxicity of H. leucospilota extract in the range of 12.5, 25, 50, 100, and 200 μg/mL concentrations for 48 hours on SK-BR-3 and MCR5 cells was determined.
[Molecular Biology Reports]
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Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia

Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.
[Cancer Immunology Immunotherapy]
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Overexpression of miR-375 Reverses the Effects of Dexamethasone on the Viability, Migration, Invasion and Apoptosis of Human Airway Epithelial Cells by Targeting DUSP6

The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.
[International Journal of Molecular Medicine]
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Inhibitory Effect of Roburic Acid in Combination with Docetaxel on Human Prostate Cancer Cells

The potential synergistic anticancer effect and the underlying mechanisms of roburic acid in combination with docetaxel on prostate cancer were investigated.
[Journal of Enzyme inhibition and Medicinal Chemistry]
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Long Noncoding RNA LUCAT1 Enhances the Survival and Therapeutic Effects of Mesenchymal Stromal Cells Post-myocardial Infarction

Using unbiased transcriptome profiling of hypoxia-preconditioned MSCs and normoxic MSCs, scientists identified a lncRNA named lung cancer-associated transcript 1 (LUCAT1) under hypoxia.
[Molecular Therapy-Nucleic Acids]
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Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.
[Bioengineered]
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L-methionine Prevents β-Cell Damage by Modulating the Expression of Arx, MafA and Regulation of FOXO1 in Type 1 Diabetic Rats

Researchers investigated the effect of L-Met on streptozotocin-induced β-cell damage model of diabetes mellitus in Sprague Dawley rats. At the end of study biochemical parameters, immunoblotting, qRT-PCR and ChIP-qPCR were performed.
[Acta Histochemica]
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The Isoflavone Puerarin Exerts Anti-Tumor Activity in Pancreatic Ductal Adenocarcinoma by Suppressing mTOR-Mediated Glucose Metabolism

The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.
[Aging]
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Dapagliflozin Attenuates Pressure Overload-Induced Myocardial Remodeling in Mice via Activating SIRT1 and Inhibiting Endoplasmic Reticulum Stress

In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.
[Acta Pharmacologica Sinica]
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Anti-Breast Cancer Synthetic Peptides Derived from the Anabas testudineus Skin Mucus Fractions

The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.
[Scientific Reports]
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