Long Non-Coding RNA PVT1 Facilitates High Glucose-Induced Cardiomyocyte Death Through the miR-23a-3p/CASP10 Axis

Investigators observed that plasmacytoma variant translocation 1 (PVT1) and caspase‐10 were upregulated while miR‐23a‐3p was downregulated in high glucose‐induced cardiomyocytes. High glucose repressed cardiomyocyte activity and induced cardiomyocyte apoptosis, but this influence was antagonized by PVT1 knockdown or miR‐23a‐3p overexpression.
[Cell Biology International]
Xia, Y.-W., & Wang, S.-B. (n.d.). Long non-coding RNA PVT1 facilitates high glucose-induced cardiomyocyte death through the miR-23a-3p/CASP10 axis. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11479 Cite
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Shrimp Shells Extracted Chitin in Silver Nanoparticle Synthesis: Expanding Its Prophecy towards Anticancer Activity in Human Hepatocellular Carcinoma HepG2 Cells

The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032 Cite
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Diltiazem Potentiates the Cytotoxicity of Gemcitabine and 5-Fluorouracil in PANC-1 Human Pancreatic Cancer Cells through Inhibition of P-Glycoprotein

The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
[Life Sciences]
El-Mahdy, H. A., El-Husseiny, A. A., Kandil, Y. I., & Gamal El-Din, A. M. (2020). Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. Life Sciences, 118518. https://doi.org/10.1016/j.lfs.2020.118518 Cite
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Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
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Modeling the Function of BAX and BAK in Early Human Brain Development Using iPSC-Derived Systems

Scientists generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells, neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development.
[Cell Death & Disease]
Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems | Cell Death & Disease. (n.d.). Retrieved September 25, 2020, from https://www.nature.com/articles/s41419-020-03002-x Cite
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Discovery of a Novel Dual-Target Inhibitor against RSK1 and MSK2 to Suppress Growth of Human Colon Cancer

The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
[Oncogene]
Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer | Oncogene. (n.d.). Retrieved September 24, 2020, from https://www.nature.com/articles/s41388-020-01467-w Cite
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Combined Treatment With Silver Graphene Quantum Dot, Radiation, and 17-AAG Induces Anticancer Effects in Breast Cancer Cells

Researchers investigated the possible anticancer effects of radiation in combination with 17-allylamino-17-demethoxy geldanamycin (17-AAG) and silver graphene quantum dot in breast cancer cells.
[Journal of Cellular Physiology]
Combined treatment with silver graphene quantum dot, radiation, and 17‐AAG induces anticancer effects in breast cancer cells - Esgandari - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved September 9, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/jcp.30046 Cite
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Mcl-1 Targeting Strategies Unlock the Proapoptotic Potential of TRAIL in Melanoma Cells

Scientists evaluated the involvement of antiapoptotic Bcl‐2 proteins in TNF‐related apoptosis‐inducing ligand (TRAIL) resistance. They were targeted by small interfering RNA‐mediated silencing in TRAIL‐sensitive and in TRAIL‐resistant melanoma cell lines.
[Molecular Carcinogenesis]
Sarif, Z., Tolksdorf, B., Fechner, H., & Eberle, J. (n.d.). Mcl-1 targeting strategies unlock the proapoptotic potential of TRAIL in melanoma cells. Molecular Carcinogenesis, n/a(n/a). https://doi.org/10.1002/mc.23253 Cite
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Canagliflozin Attenuates Isoprenaline-Induced Cardiac Oxidative Stress by Stimulating Multiple Antioxidant and Anti-Inflammatory Signaling Pathways

Scientists investigated protective effects of canagliflozin in isoprenaline-induced cardiac oxidative stress, and their underlying molecular mechanisms in Long-Evans rat heart and in HL-1 cardiomyocyte cell lines.
[Scientific Reports]
Hasan, R., Lasker, S., Hasan, A., Zerin, F., Zamila, M., Chowdhury, F. I., Nayan, S. I., Rahman, M. M., Khan, F., Subhan, N., & Alam, M. A. (2020). Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways. Scientific Reports, 10(1), 14459. https://doi.org/10.1038/s41598-020-71449-1 Cite
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Tubeimoside I-Induced Lung Cancer Cell Death and the Underlying Crosstalk between Lysosomes and Mitochondria

Researchers report that the traditional Chinese anticancer agent tubeimoside I, which is a potent inhibitor of autophagy, can promote mitochondria-associated apoptosis in lung cancer cells.
[Cell Death & Disease]
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