Dual Akt and Bcl-2 Inhibition Induces Cell-Type Specific Modulation of Apoptotic and Autophagic Signaling in Castration Resistant Prostate Cancer Cell Lines

The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).
[Molecular Biology Reports]
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Inhibition of JAK2/STAT3 Signaling Pathway by Panaxadiol Limits the Progression of Pancreatic Cancer

Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[Aging-Us]
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Baxter Announces US Approval and Launch of Ready-to-Use Cardiovascular Medicine Norepinephrine in Premix Formulation

Baxter International, Inc. announced the US FDA approval and commercial launch of premix Norepinephrine Bitartrate in 5% Dextrose Injection.
[Baxter International Inc.]
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Chlorothalonil Induces the Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell-Based In Vitro Monolayer Model by Activating MAPK Pathway

Scientists used Caco-2 cell monolayers as an in vitro model of human intestinal epithelial barrier (IEB) to evaluate the toxicity of chlorothalonil exposure on the structure and function of IEB.
[Acta Biochimica et Biophysica Sinica]
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The Anti-Tumor Effect of Induced Pluripotent Stem Cells against Submandibular Gland Carcinoma in Rats Is Achieved via Modulation of the Apoptotic Response and the Expression of Sirt-1, TGF-β, and MALAT-1 in Cancer Cells

The authors investigated the contribution of the Bax, Sirt-1, TGF-β, and MALAT genes and/or their protein expression to the pathogenesis of submandibular carcinogenesis before and after iPSCs treatment.
[Molecular and Cellular Biochemistry]
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Atractylenolide III Induces Apoptosis by Regulating the Bax/Bcl-2 Signaling Pathway in Human Colorectal Cancer HCT-116 Cells In Vitro and In Vivo

The results showed that atractylenolide III significantly inhibited the cell growth and induce cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro.
[Anti-Cancer Drugs]
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The Petroleum Ether Extract of Brassica rapa L. Induces Apoptosis of Lung Adenocarcinoma Cells via the Mitochondria-Dependent Pathway

The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.
[Food & Function]
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Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury

The authors successfully established laparoscopic liver ischemia-reperfusion with partial hepatectomy in miniature pigs and injected saline, DMEM, adipose-derived stem cell (ADSC)-secretome, and ADSCs directly into the liver parenchyma immediately afterwards.
[Stem Cells International]
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Akt Activation-Dependent Protective Effect of Wild Ginseng Adventitious Root Protein against UVA-Induced NIH-3T3 Cell Damage

Prolonged skin exposure to ultraviolet radiation can lead to development of several acute and chronic diseases, with UVA exposure considered a primary cause of dermal photodamage. Researchers prepared a wild ginseng adventitious root extract (ARE) that could alleviate UVA irradiation-induced NIH-3T3 cell viability decline.
[Wound Repair and Regeneration]
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Effect of Extracorporeal Shock Wave Therapy on Keratinocytes Derived from Human Hypertrophic Scars

Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.
[Scientific Reports]
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Treatment during a Developmental Window Prevents NF1-Associated Optic Pathway Gliomas by Targeting Erk-Dependent Migrating Glial Progenitors

Scientists provided the proof-of-concept evidence for preventing pediatric low-grade gliomas before tumor-associated neurological damage entered an irreversible phase.
[Developmental Cell]
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