The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).
[Molecular Biology Reports]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Investigators found panaxadiol significantly inhibited proliferation, and induced apoptosis in human pancreatic cancer cell lines PANC-1 and Patu8988 in a dose-dependent manner.
[zotpress userid=” items=’ARAWWK92′ style=’apa’ cite=’yes’]
Baxter International, Inc. announced the US FDA approval and commercial launch of premix Norepinephrine Bitartrate in 5% Dextrose Injection.
[Baxter International Inc.]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Scientists used Caco-2 cell monolayers as an in vitro model of human intestinal epithelial barrier (IEB) to evaluate the toxicity of chlorothalonil exposure on the structure and function of IEB.
[Acta Biochimica et Biophysica Sinica]
[zotpress userid=” items=’FGIESPJX’ style=’apa’ cite=’yes’]
The authors investigated the contribution of the Bax, Sirt-1, TGF-β, and MALAT genes and/or their protein expression to the pathogenesis of submandibular carcinogenesis before and after iPSCs treatment.
[Molecular and Cellular Biochemistry]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
The results showed that atractylenolide III significantly inhibited the cell growth and induce cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro.
[zotpress userid=” items=’PVXGQVEU’ style=’apa’ cite=’yes’]
The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.
[Food & Function]
[zotpress userid=” items=’9UU4TDCC’ style=’apa’ cite=’yes’]
The authors successfully established laparoscopic liver ischemia-reperfusion with partial hepatectomy in miniature pigs and injected saline, DMEM, adipose-derived stem cell (ADSC)-secretome, and ADSCs directly into the liver parenchyma immediately afterwards.
[Stem Cells International]
[zotpress userid=” items=’U3HWRCRE’ style=’apa’ cite=’yes’]
Prolonged skin exposure to ultraviolet radiation can lead to development of several acute and chronic diseases, with UVA exposure considered a primary cause of dermal photodamage. Researchers prepared a wild ginseng adventitious root extract (ARE) that could alleviate UVA irradiation-induced NIH-3T3 cell viability decline.
[Wound Repair and Regeneration]
[zotpress userid=” items=’AFPGBBC6′ style=’apa’ cite=’yes’]
Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.
[zotpress userid=” items=’35SQQIJG’ style=’apa’ cite=’yes’]
Scientists provided the proof-of-concept evidence for preventing pediatric low-grade gliomas before tumor-associated neurological damage entered an irreversible phase.
[zotpress userid=” items=’9TJZQUGK’ style=’apa’ cite=’yes’]