Investigators observed that plasmacytoma variant translocation 1 (PVT1) and caspase‐10 were upregulated while miR‐23a‐3p was downregulated in high glucose‐induced cardiomyocytes. High glucose repressed cardiomyocyte activity and induced cardiomyocyte apoptosis, but this influence was antagonized by PVT1 knockdown or miR‐23a‐3p overexpression.
[Cell Biology International]
The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
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Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032 Cite
The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
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El-Mahdy, H. A., El-Husseiny, A. A., Kandil, Y. I., & Gamal El-Din, A. M. (2020). Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. Life Sciences, 118518. https://doi.org/10.1016/j.lfs.2020.118518 Cite
Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
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Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Scientists generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells, neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development.
[Cell Death & Disease]
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Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems | Cell Death & Disease. (n.d.). Retrieved September 25, 2020, from https://www.nature.com/articles/s41419-020-03002-x Cite
The authors identified a novel dual-target inhibitor, APIO-EE-07, that could block both RSK1 and MSK2 kinase activity in a dose-dependent manner. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
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Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer | Oncogene. (n.d.). Retrieved September 24, 2020, from https://www.nature.com/articles/s41388-020-01467-w Cite
Researchers investigated the possible anticancer effects of radiation in combination with 17-allylamino-17-demethoxy geldanamycin (17-AAG) and silver graphene quantum dot in breast cancer cells.
[Journal of Cellular Physiology]
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Combined treatment with silver graphene quantum dot, radiation, and 17‐AAG induces anticancer effects in breast cancer cells - Esgandari - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved September 9, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/jcp.30046 Cite
Scientists evaluated the involvement of antiapoptotic Bcl‐2 proteins in TNF‐related apoptosis‐inducing ligand (TRAIL) resistance. They were targeted by small interfering RNA‐mediated silencing in TRAIL‐sensitive and in TRAIL‐resistant melanoma cell lines.
Scientists investigated protective effects of canagliflozin in isoprenaline-induced cardiac oxidative stress, and their underlying molecular mechanisms in Long-Evans rat heart and in HL-1 cardiomyocyte cell lines.
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Hasan, R., Lasker, S., Hasan, A., Zerin, F., Zamila, M., Chowdhury, F. I., Nayan, S. I., Rahman, M. M., Khan, F., Subhan, N., & Alam, M. A. (2020). Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways. Scientific Reports, 10(1), 14459. https://doi.org/10.1038/s41598-020-71449-1 Cite
Researchers report that the traditional Chinese anticancer agent tubeimoside I, which is a potent inhibitor of autophagy, can promote mitochondria-associated apoptosis in lung cancer cells.
[Cell Death & Disease]
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