Transcriptional Network Constituted of CBP, Ku70, NOX2, and BAX Prevents the Cell Death of Necrosis, Paraptosis, and Apoptosis in Human Melanoma

Knocking down CREB-binding protein or Ku70 induced necrotic and paraptotic cell death as indicated by high-level intracellular reactive oxygen species, cytoplasmic vacuolization, and cell cycle arrest in the S phase.
[Cell Death Discovery]
Ding, L., Wen, Y., Zhang, X., Zhao, F., Lv, K., Shi, J., Shen, S., & Pan, X. (2021). Transcriptional network constituted of CBP, Ku70, NOX2, and BAX prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma. Cell Death Discovery, 7(1), 1–15. https://doi.org/10.1038/s41420-021-00417-z Cite
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The Application of BH3 Mimetics in Myeloid Leukemias

As the number and variety of available BH3 mimetics increases, and investigations into applying these novel inhibitors to treat myeloid leukemias continue apace the need to evaluate where the science currently stands in this rapidly expanding field is clear.
[Cell Death & Disease]
Parry, N., Wheadon, H., & Copland, M. (2021). The application of BH3 mimetics in myeloid leukemias. Cell Death & Disease, 12(2), 1–13. https://doi.org/10.1038/s41419-021-03500-6 Cite
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Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress

The authors sensitized androgen-independent and TRAIL-resistant prostate cancer cells to TRAIL-mediated apoptosis via taxane therapy and examined the mechanism of sensitization.
[Molecular Cancer Therapeutics]
Grayson, K. A., Hope, J. M., Wang, W., Reinhart-King, C. A., & King, M. R. (2021). Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0495 Cite
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Lactonic Sophorolipid–Induced Apoptosis in Human HepG2 Cells through the Caspase-3 Pathway

The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology]
Wang, X., Xu, N., Li, Q., Chen, S., Cheng, H., Yang, M., Jiang, T., Chu, J., Ma, X., & Yin, D. (2021). Lactonic sophorolipid–induced apoptosis in human HepG2 cells through the Caspase-3 pathway. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-020-11045-5 Cite
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Improvement of Sensory Neuron Growth and Survival via Negatively Regulating PTEN by miR-21-5p-Contained Small Extracellular Vesicles from Skin Precursor-Derived Schwann Cells

The authors showed that skin precursor-derived Schwann cells –derived extracellular vesicles could improve the neurite outgrowth of dorsal root ganglions and sensory neurons.
[Stem Cell Research & Therapy]
Cong, M., Shen, M., Wu, X., Li, Y., Wang, L., He, Q., Shi, H., & Ding, F. (2021). Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells. Stem Cell Research & Therapy, 12(1), 80. https://doi.org/10.1186/s13287-020-02125-4 Cite
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Enhancer of Zeste Homolog 2-Mediated Paired Box 8 Methylation Promotes Gastrointestinal Stromal Tumor Progression through Wnt4 Downregulation

The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured.
[Cancer Gene Therapy]
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p53 Is Required for Nuclear but Not Mitochondrial DNA Damage-Induced Degeneration

Researchers induced selective mitochondrial DNA damage in neuronal axons using microfluidic chambers that allowed for the spatial and fluidic isolation of neuronal cell bodies from the axons.
[Cell Death & Disease]
Geden, M. J., Romero, S. E., & Deshmukh, M. (2021). p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration. Cell Death & Disease, 12(1), 1–11. https://doi.org/10.1038/s41419-020-03373-1 Cite
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The Mitochondrial Protein ERAL1 Suppresses RNA Virus Infection by Facilitating RIG-I-Like Receptor Signaling

Investigators identified the mitochondrial protein ERA G-protein-like 1 as a mitochondrial antiviral signaling protein-interacting protein by using proximity-based labeling technology.
[Cell Reports]
Li, S., Kuang, M., Chen, L., Li, Y., Liu, S., Du, H., Cao, L., & You, F. (2021). The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Cell Reports, 34(3). https://doi.org/10.1016/j.celrep.2020.108631 Cite
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Survival Control of Oligodendrocyte Progenitor Cells Requires the Transcription Factor 4 during Olfactory Bulb Development

Investigators identified that the transcription factor 4-mediated cell death was essential for generating an appropriate number of oligodendrocyte progenitor cells and thereby oligodendrocytes in the olfactory bulb.
[Cell Death & Disease]
Zhang, Y., Cai, Y., Wang, Y., Deng, X., Zhao, Y., Zhang, Y., & Xie, Y. (2021). Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03371-3 Cite
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Cyclophilin A Inhibits A549 Cell Oxidative Stress and Apoptosis by Modulating the PI3K/Akt/mTOR Signaling Pathway

Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
[Bioscience Reports]
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Integrin α2β1 Inhibition Attenuates Prostate Cancer Cell Proliferation by Cell Cycle Arrest, Promoting Apoptosis and Reducing Epithelial-Mesenchymal Transition

Investigators examined the effects of the inhibitor BTT‐3033, which selectively interferes with the connection between integrin a2b1 and its ligand, on migration, epithelial–mesenchymal transition, cell cycle arrest, apoptosis, and specific intracellular signaling pathways using LNcap‐FGC and DU‐145 prostate cancer cell lines.
[Journal of Cellular Physiology]
Salemi, Z., Azizi, R., Fallahian, F., & Aghaei, M. (n.d.). Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial–mesenchymal transition. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30202 Cite
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