Bax

[Scientific Reports] Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.

[Cell Death Discovery] Scientists found that lenalidomide, a representative of immunomodulatory drugs (IMiDs), specifically induced accumulation of Ik6 with the disappearance of functional isoforms within 24 hours in Ik6-positive Philadelphia chromosome-positive acute lymphoblastic leukemia cells in a neddylation-dependent manner.

[Scientific Reports] Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.

[Biochemical Genetics] Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.

[Scientific Reports] The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.

[Cancer Gene Therapy] Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.