IMiDs Uniquely Synergize with TKIs to Upregulate Apoptosis of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Cells Expressing a Dominant-Negative IKZF1 Isoform

Scientists found that lenalidomide, a representative of immunomodulatory drugs (IMiDs), specifically induced accumulation of Ik6 with the disappearance of functional isoforms within 24 hours in Ik6-positive Philadelphia chromosome-positive acute lymphoblastic leukemia cells in a neddylation-dependent manner.