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Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis

[Evidence-Based Complementary and Alternative Medicine] After warm acupuncture combined with bone-marrow MSCs, the Modified Lequesne MG knee joint assessment scale was used to evaluate the degree of knee joint behavior, the Taiping Peng method generally observed the histomorphology changes of knee osteoarthritis rabbit cartilage, and hematoxylin-eosin staining, safranin O green staining, and toluidine blue staining were conducted to evaluate the extent of cartilage tissue pathology.

Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line

[Cardiovascular Toxicology] To investigate the role of CAIII in the apoptosis of myocytes under hypoxic conditions and facilitate the strategy for treating hypoxia-induced damage, in vitro experiments in H9c2 were employed.

Importance of Bcl-2-Family Proteins in Murine Hematopoietic Progenitor and Early B Cells

[Cell Death & Disease] Investigators suggested that the main role of Bim in hematopoietic cells was the neutralization of Mcl-1, identified a number of likely molecular events during the maintenance of survival and the induction of apoptosis in mouse hematopoietic progenitor cells, and provided data on the regulation of expression and importance of these proteins during differentiation along the B cell lineage.

Dexamethasone Induces Pancreatic β-Cell Apoptosis through Upregulation of TRAIL Death Receptor

[Journal of Molecular Endocrinology] A mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the TRAIL pathway was investigated in cultured cells and isolated mouse islets.

Trilobolide-6-O-Isobutyrate Suppresses Hepatocellular Carcinoma Tumorigenesis through Inhibition of IL-6/STAT3 Signaling Pathway

[Phytotherapy Research] Researchers reported a compound, trilobolide-6-O-isobutyrate, isolated from the flowers of Wedelia trilobata with a markedly cytotoxic effect on hepatocellular carcinoma cells.

Mechanism of TCONS_00147848 Regulating Apoptosis of Nasal Mucosa Cells and Alleviating Allergic Rhinitis through FOSL2-Mediated JAK/STAT3 Signaling Pathway

[Scientific Reports] Researchers explored the roles and related mechanisms of lncRNA-TCONS_00147848 in nasal mucosa cell apoptosis and allergic rhinitis (AR). AR mice were sensitized with ovalbumin, with the TCONS_00147848 interference lentiviral vector and FOSL2 overexpressing lentiviral vectors constructed respectively.

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