CD8

[Open Biology] Researchers developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

[Journal of Immunology] Investigators developed a protocol to generate stable numbers of liver-located CD8 T cells, and used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice.

[Bone Marrow Transplantation] Scientists investigated whether gilteritinib, a selective FLT3 inhibitor, could enhance graft-versus-leukemia effects against FLT3 internal tandem duplication mutant transfected Ba/F3 leukemia in mice.

[Cell Reports] Investigators showed that creatine supported cell-intrinsic CD8+ T cell homeostasis. They identified creatine kinase B as the creatine kinase isoenzyme that supported these T cell properties.

[Cancer Cell] Mechanistically, IFNγ stimulated ACSL4 and altered tumor cell lipid pattern, thereby increasing incorporations of arachidonic acid into C16 and C18 acyl chain-containing phospholipids.

[Cell Reports] Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions