CD8

[Aging] Investigators indicated that TEAD2/4 were significantly upregulated in HCC compared with normal tissues. Downregulation of TEAD2 promoted the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.

[Cellular and Molecular Life Sciences] Scientists established cultures of murine bone marrow-derived dendritic cells that lacked sialic acid expression using a sialic acid-blocking mimetic Ac53FaxNeu5Ac.

[Science Advances] Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.

[NPJ Regenerative Medicine] Using a defined engineered thymic niche system, investigators undertook a multi-stage statistical learning-based optimization campaign and identified IL-3 and tumor necrosis factor α as a stage- and dose-specific enhancers of cell proliferation and T-lineage differentiation.

[Science Advances] By grafting alloskin or heart into severe combined immunodeficient or Rag2KO mice in which a piece of induced CD4+ and/or CD8+ tissue-resident memory (TRM) cell–containing MHC-matched or syngeneic skin was transplanted in advance, scientists addressed this issue.

[Journal of Leukocyte Biology] Investigators used Oncomine and The Cancer Genome Atlas databases to analyze the transcription and survival effect of N-acetylgalactosaminyltransferase genes (GALNTs) in pan-cancer.