CD8

[Scientific Reports] Scientists developed DNA methylation markers that recapitulated the densities of tumor-infiltrating lymphocytes in gastric carcinoma.

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that lymph node CD169+ macrophages were dependent on direct lymphotoxin beta receptor signaling.

[Clinical Cancer Research] Researchers assessed regulatory T cells and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus; and hematopoietic stem and progenitor cells in the bone marrow.

[Nature Communications] Scientists found that intermittent but not daily dosing of a PI3Kα/β/δ inhibitor, BAY1082439, on Pten-null prostate cancer models could overcome immune checkpoint therapy resistance and unleash CD8+ T cell-dependent anti-tumor immunity in vivo.

[Journal of Immunology] The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.

[Oncogene] Scientists reported that both PD-L1 and JMJD2D were frequently overexpressed in human colorectal cancer specimens with a significant positive correlation.