CD8

[Molecular Therapy] In vivo xenograft experiments confirmed D2HGDH-OE CAR-T cell decreased serum D-2-hydroxyglutarate (D2HG) and improved the overall survival of mice bearing NALM6 cancer cells with mutation IDH1.

[Oncoimmunology] The authors investigated the efficacy of CD29- and CD44-targeted NIR-PIT (CD29-PIT and CD44-PIT, respectively) in the B16 melanoma model, which was highly pigmented.

[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.

[Nature Communications] Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.

[Molecular Biology Reports] IL-21 has profound effects on tumor growth and immunosurveillance of colitis-associated tumourigenesis, thereby emphasising its involvement in the pathogenesis of colorectal cancer.

[Vaccine] Investigators identified immunodominant portions of four malaria vaccine candidate antigens using peripheral blood mononuclear cells from adults with life-long exposure to malaria parasites.