D2HGDH-Mediated D2HG Catabolism Enhances the Anti-Tumor Activities of CAR-T Cells in an Immunosuppressive Microenvironment

In vivo xenograft experiments confirmed D2HGDH-OE CAR-T cell decreased serum D-2-hydroxyglutarate (D2HG) and improved the overall survival of mice bearing NALM6 cancer cells with mutation IDH1.