CD8

[Nature Communications] Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.

[Cancer Discovery] The authors found that SHP2 inhibitor treatment depleted alveolar and M2-like macrophages, induced tumor-intrinsic CCL5/CXCL10 secretion and promoted B and T lymphocyte infiltration in Kras- and Egfr-mutant non-small cell lung cancer.

[Cell Research] Investigators developed a next-generation IL-15 that is activated inside the tumor microenvironment.

[Cell Reports] Using affinity purification/mass spectrometry, researchers identified cyclin K and cyclin-dependent kinase 13 as a Nef-associated kinase complex.

[NPJ Vaccines] Scientists demonstrated that a liver stage-specific autophagy mutant of Plasmodium berghei, when used as a live vaccine under a chemoprophylaxis vaccination (CVac) regimen, provided superior long-lasting protection, in both inbred and outbred mice, as compared to WT-CVac.

[Molecular Therapy] Scientists isolated a broad range of promising TCRs targeting multiple antigens for treatment of B-cell malignancies. 28 target genes for B-cell malignancies were selected based on gene expression profiles.