CD8

[Nature] Scientists identified mutation-associated neoantigens (MANA)-specific T cell clones using the MANA functional expansion of specific T cells assay3 in neoadjuvant anti-PD-1-treated non-small cell lung cancers.

[Proceedings of the National Academy of Sciences of the United States of America] Leveraging the use of mass cytometry combined with multiplex major histocompatibility complex class I tetramer staining, researchers screened and identified tumor neoantigen–specific CD8+ T cells in the Lewis Lung carcinoma tumor model.

[Cell Reports] Genetic deletion or methylation of DNA-sensing/IFN genes or CCL5 chemokine was identified as a potential mechanism to attenuate T cell inflammation.

[Journal of Clinical Investigation] In mice, lack of PTPN22 augmented antitumor activity with greater infiltration and activation of macrophages, natural killer (NK) cells, and T cells.

[Science Signaling] Increasing or decreasing Syk activity by stimulating the γδ T cell receptor (TCRγδ) or inhibiting Syk, respectively, substantially reduced γδ17 cell numbers.

[Nature] Scientists showed, by linking the antigenic specificity of TCRs and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumor specificity shaped the expression state of intratumoural CD8+ T cells.