CD8

[Scientific Reports] The authors focused on potential immunotherapy for giant cell tumor of bone (GCTB) and investigated the tumor microenvironment of GCTB.

[Nature Immunology] Overexpression of BATF in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, and decreased the expression of inhibitory receptors.

[Immunity] Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver, and tumor tissues from 46 HCC patients, researchers detected 91 different antigen-specific CD8+ T cell populations targeting HBV, neoantigen, tumor-associated, and disease-unrelated antigens.

[Nature Immunology] The authors showed that clinically applied adenovirus vectors preferentially targeted fibroblastic stromal cells in cultured human tissues.

[Cell Discovery] Scientists performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of Parkinson’s disease.

[Nature Immunology] The authors demonstrated that CX3CR1+ effector cells bear a striking similarity to short-lived effector cells during acute infection.