CXCR4 Inhibition in Human Pancreatic and Colorectal Cancers Induces an Integrated Immune Response

Inhibiting CXCR4 in an experimental cancer medicine study by one week continuous infusion of the small-molecule inhibitor AMD3100 induced an integrated immune response that was detected by transcriptional analysis of paired biopsies of metastases from patients with microsatellite stable colorectal and pancreatic cancer.
[Proceedings of the National Academy of Sciences of the United States of America]
Biasci, D., Smoragiewicz, M., Connell, C. M., Wang, Z., Gao, Y., Thaventhiran, J. E. D., Basu, B., Magiera, L., Johnson, T. I., Bax, L., Gopinathan, A., Isherwood, C., Gallagher, F. A., Pawula, M., Hudecova, I., Gale, D., Rosenfeld, N., Barmpounakis, P., Popa, E. C., … Jodrell, D. I. (2020). CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2013644117 Cite
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Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury by Inhibiting the Proinflammatory Function of Ly6C+ CD8+ T Cells

Investigators showed that CD8+ T cells played an important role in MSC-mediated acute lung injury remission, and both infiltration quantity and proinflammatory function were inhibited by MSCs, indicating a potential mechanism for therapeutic intervention.
[Cell Death & Disease]
Zhu, J., Feng, B., Xu, Y., Chen, W., Sheng, X., Feng, X., Shi, X., Liu, J., Pan, Q., Yu, J., Li, L., & Cao, H. (2020). Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C + CD8 + T cells. Cell Death & Disease, 11(10), 1–11. https://doi.org/10.1038/s41419-020-03036-1 Cite
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Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 Axes Contributes to Antitumor Effects in a Mouse Model of Malignant Glioma

Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
[Scientific Reports]
Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
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A Bilateral Tumor Model Identifies Transcriptional Programs Associated with Patient Response to Immune Checkpoint Blockade

Researchers introduced a resection and response-assessment approach for studying the tumor microenvironment before or shortly after treatment initiation to identify predictive biomarkers differentiating responders from nonresponders.
[Proceedings of the National Academy of Sciences of the United States of America]
Chen, I. X., Newcomer, K., Pauken, K. E., Juneja, V. R., Naxerova, K., Wu, M. W., Pinter, M., Sen, D. R., Singer, M., Sharpe, A. H., & Jain, R. K. (2020). A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2002806117 Cite
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In Vivo Antiviral Host Transcriptional Response to SARS-CoV-2 by Viral Load, Sex, and Age

Scientists examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA sequencing profiles of nasopharyngeal swabs from 430 individuals with PCR-confirmed SARS-CoV-2 and 54 negative controls.
[PLoS Biology]
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CXCR3 and Cognate Ligands Are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) microarray and TCGA datasets were analyzed to identify cytokines and cognate receptors overexpressed in PDAC and associated with survival.
[Clinical Cancer Research]
Batra, S. K., Cannon, A., Thompson, C. M., Maurer, C., Atri, P., Bhatia, R., West, S., Ghersi, D., Olive, K. P., & Kumar, S. (2020). CXCR3 and Cognate Ligands Are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1359 Cite
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