EMT

[Cell Death & Disease] Scientists found that higher expression of neurite outgrowth inhibitor B (Nogo-B) was detected in nasopharyngeal carcinoma (NPC) cells and tissues. Higher expression of Nogo-B was statistically relevant to N stage, M stage, and poor prognosis in NPC patients.

[Oncogene] The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.

[Cell Death & Disease] HERC3 was indicated to inhibit the migration, invasion and metastasis in vitro and in vivo through transwell assays, wound healing assays and vivo experiments.

[Cancer Gene Therapy] Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal-like (MES-) TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.

[npj Breast Cancer] Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.

[Cell Death & Disease] The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through Aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.