POLE2 Facilitates the Malignant Phenotypes of Glioblastoma through Promoting AURKA-Mediated Stabilization of FOXM1

The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through Aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.